1. MAOIs-sympathomimetic agents
- MAO acts to break down catecholamines (norepinephrine) since enzyme is
dysfunctional, concentration of its within adrenergic neurons increase and
these drug may intervene to break down.
2. MAOIs-tricyclic antidepressants
- Atropine-like reaction, tremors, convulsions, hyperthermia and vascular
collapse resulted the combination use of MAOI with tricyclic antidepressants.
3. MAOIs-SSRI
- Combined both agent lead to death report said. SSRI (citalopram, escitalopram,
fluoxetine, fluvoxamine, paroxetine, sertaline) with MAOI is contraindicated.
Fluoxetine has a long life concentration in the blood when used for the first
line may take 5 weeks to yield for excretion before administrating MAOI.
4. Guanethidine-tricyclic antidepressants
- Guanethidine site action is adrenergic neuron and may uptake norepinephrine
as well as indirectly acting to ephedrine and amphetamine.
- It plays anti hypertensive action. Even showed that antipsychotic agent may
inhibit guanethidine (chlorpromazine) and haloperidol then other agents like
tricyclic antidepressants reduce the antihypertensive effects of guanethid
Sunday, June 25, 2017
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