1. Penicillins-probenecid
- probenecid approved to play a role in the tubular by blocking the secretion of
penicillin then enhance the concentration, effectiveness by the factor of 2-fold
to 4-fold elevation of serum also it decreases renal excretion of methotrexate.
2. Methotrexate-NSAIDs
- NSAIDs increase the activity and toxicity of methotrexate also toxicity to
ketoprofen.
Tuesday, June 20, 2017
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